By Ramesh N. Patel
Written via the world over well-known scientists in biocatalysis, the authors examine the synthesis of chiral intermediates for over 60 brand-name prescribed drugs for a variety of drug treatments and coverings. From beginning fabric to product, the chapters supply special mechanisms that convey chiral intermediates and different by-products for every reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. state of the art issues contain complex methodologies for gene shuffling and directed evolution of biocatalysts; the customized engineering of enzymes; using microbial cells and remoted biocatalysts; using renewable beginning fabrics; and producing novel molecules by way of combinatorial biocatalysis and high-throughput screening.
Focusing on commercial purposes, the booklet additionally considers elements reminiscent of bulk tactics, instrumentation, solvent choice, and strategies for catalyst immobilization, reusability, and yield optimization all through. Biocatalysis within the Pharmaceutical and Biotechnology Industries showcases the sensible merits and methodologies for utilizing biocatalysts to boost and bring chiral prescribed drugs and superb chemicals.
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Additional info for Biocatalysis in the Pharmaceutical and Biotechnology Industries
Biocatalysis in the Pharmaceutical and Biotechnology Industries by Ramesh N. Patel