Download e-book for kindle: Biotransformation and Metabolite Elucidation of Xenobiotics: by Ala F. Nassar

By Ala F. Nassar

The objective of this e-book is to enhance the readers' wisdom of metabolite elucidation in drug metabolism via exposing them to extensive insurance of the biotransformation of xenobiotics, ideas for picking out and characterizing metabolites, FDA guidance, and case reports on the best way to enhance the decision-making approach in structural amendment of drug applicants to minimize toxicity.

The publication contains eight chapters; it first offers an advent on biotransformation of xenobiotics, after which offers glossy techniques and methods for facing metabolite characterization, utilizing instruments akin to LC-MS, H-D trade, good isotopes LC-MS-NMR, and radiolabeled compounds. additionally, concepts for facing reactive intermediates in drug discovery and improvement are offered in addition to case stories on enhancing the decision-making procedure within the structural amendment of drug applicants. The final bankruptcy discusses the regulatory views of defense checking out of drug metabolites and why, how, and whilst to check their safety.

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Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification by Ala F. Nassar

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