Bispecific Antibodies by Roland E. Kontermann (Ed.),Roland E. Kontermann PDF

By Roland E. Kontermann (Ed.),Roland E. Kontermann

The proposal of utilizing bispecific antibodies for melanoma treatment through retargeting immune effector cells was once constructed a number of years in the past. preliminary medical reports have been really disappointing often as a result of low efficacy, critical uncomfortable side effects and the immunogenicity of the bispecific antibodies. The development in antibody engineering ultimately ended in the new release of latest sessions of bispecific antibodies missing those hindrances. furthermore, new purposes have been proven, similar to pre-targeting options in radioimmunotherapy and twin concentrating on ways that allows you to enhance binding, selectivity and efficacy.

In this ebook, the several methods of producing bispecific antibodies are defined, with emphasis on recombinant codecs. many of the functions of bispecific antibodies, e.g. in mobile melanoma immunotherapy, radioimmunotherapy and pretargeting options are coated, and rising functions resembling twin concentrating on concepts, which contain the simultaneous inhibition of 2 objectives, are addressed.

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Bispecific Antibodies by Roland E. Kontermann (Ed.),Roland E. Kontermann

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