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By Alan L. Rothman (Ed.),Alan L. Rothman

Scientific study on dengue has a protracted and wealthy heritage. The literature has been touched via recognized names in drugs- Benjamin Rush, Walter Reed, and Albert Sabin, to call a truly few- and has been fertile flooring for scientific historians . The advances made in these early investigations are all of the extra notable for the restricted instruments to be had on the time. The demonstration of a viral etiology for dengue fever, the popularity of mosquitoes because the vector for transmission to people, and the lifestyles of a number of viral variations (serotypes) with purely partial cross-protection have been all comprehensive sooner than the facility to tradition and symbolize the etiologic agent. examine on dengue during this interval was once often pushed through situations. Epidemics of dengue created public wellbeing and fitness crises, even supposing those have been quite short-lived in anybody situation, because the inhabitants of weak contributors fast shrank. army concerns turned as an incredible motive force for learn. With the creation of enormous numbers of non-immune members into endemic parts, dengue may perhaps cripple army readiness, taking extra infantrymen out of motion than antagonistic hearth. Dengue and dengue hemorrhagic fever, which assumed pandemic proportions through the latter 1/2 the final century, have proven no indication of slowing their development in this first decade of the twenty-first century. demanding situations stay in figuring out the elemental mechanisms of viral replication and illness pathogenesis, in medical administration of sufferers, and answerable for dengue viral transmission. however, new instruments and insights have resulted in significant fresh medical advances. because the first candidate vaccines input large-scale efficacy trials, there's cause to pray that we may well quickly "turn the nook" in this disease.

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Dengue Virus: 338 (Current Topics in Microbiology and Immunology) by Alan L. Rothman (Ed.),Alan L. Rothman


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